Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Xiaohong Xu1, Vinothakumar Rajamanicham1, Sujing Xu1

  • 1Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 4, 2019
PubMed

Insights

Schisandrin A (SchA) shows promise for treating triple-negative breast cancer (TNBC). This compound inhibits TNBC cell growth by inducing apoptosis and cell cycle arrest, offering a potential new therapeutic strategy.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Triple-negative breast cancer (TNBC) lacks effective therapeutic targets.
  • Schisandrin A (SchA), a phytochemical from Schisandra chinensis, has potential anti-cancer properties.

Purpose of the Study:

  • To evaluate the anti-cancer effects and mechanisms of SchA in TNBC.
  • To investigate SchA's impact on Wnt signaling and ER stress in TNBC cells.

Main Methods:

  • In vitro studies using MDA-MB-231 and BT-549 TNBC cell lines.
  • In vivo evaluation in a xenograft mouse model.
  • Analysis of cell cycle, apoptosis, Wnt signaling, and ER stress pathways.

Main Results:

  • SchA significantly inhibited TNBC cell growth, inducing cell cycle arrest and apoptosis.
  • SchA suppressed the overactivated Wnt signaling pathway in TNBC cells.
  • SchA treatment activated ER stress in TNBC cells, confirmed in a xenograft model.

Conclusions:

  • SchA demonstrates potent anti-cancer activity against TNBC in preclinical models.
  • The mechanism involves inducing cell cycle arrest and apoptosis via regulation of Wnt/ER stress signaling.
  • SchA represents a potential therapeutic candidate for TNBC treatment.
Keywords:
ER stressSchisandrin ATriple negative breast cancerWnt

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