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Updated: Jan 25, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Modeling and simulation of hypothermia effects on cardiac electrical dynamics
Youssef Belhamadia1, Justin Grenier2
1Department of Mathematics and Statistics, American University of Sharjah, Sharjah, United Arab Emirates.
Abstract:
Previous experimental evidence has shown the effect of temperature on the action potential duration (APD). It has also been demonstrated that regional cooling of the heart can prolong the APD and promote the termination of ventricular tachycardia. The aim of this study is to demonstrate the effect of hypothermia in suppressing cardiac arrhythmias using numerical modeling. For this purpose, we developed a mathematical model that couples Pennes' bioheat equation and the bidomain model to simulate the effect of heat on the cardiac action potential. The simplification of the proposed heat-bidomain model to the heat-monodomain model is provided. A suitable numerical scheme for this coupling, based on a time adaptive mesh finite element method, is also presented. First, we performed two-dimensional numerical simulations to study the effect of heat on a regular electrophysiological wave, with the comparison of the calculated and experimental values of Q10. Then, we demonstrated the effect of global hypothermia in suppressing single and multiple spiral waves.
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