Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostaglandins and the developing kidney.

C A Gleason

    Seminars in Perinatology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Prostaglandins are vital for fetal and neonatal kidney development, influencing renal function and fluid balance. Indomethacin can cause transient renal dysfunction in newborns, highlighting the importance of careful monitoring.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluating patterns of morphine use in a neonatal intensive care unit after NEOPAIN.

    Journal of neonatal-perinatal medicine·2014
    Same author

    The nematode-resistance gene, Mi-1, is associated with an inverted chromosomal segment in susceptible compared to resistant tomato.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2004
    Same author

    Fetal cerebral and peripheral circulatory responses to hypoxia after nitric oxide synthase inhibition.

    American journal of physiology. Regulatory, integrative and comparative physiology·2001
    Same author

    Blood-brain barrier permeability during dopamine-induced hypertension in fetal sheep.

    Journal of applied physiology (Bethesda, Md. : 1985)·2001
    Same author

    Time dependent smooth muscle regeneration and maturation in a bladder acellular matrix graft: histological studies and in vivo functional evaluation.

    The Journal of urology·2001
    Same author

    Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep.

    American journal of physiology. Heart and circulatory physiology·2000
    Same journal

    Congenital cytomegalovirus: Screening strategies and diagnostic challenges.

    Seminars in perinatology·2026
    Same journal

    The society for neonatal nutrition and lifelong health: Building science and translating research to inform neonatal nutritional care.

    Seminars in perinatology·2026
    Same journal

    Enteral nutrition to optimize health and neurodevelopmental outcomes in very preterm infants.

    Seminars in perinatology·2026
    Same journal

    Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit.

    Seminars in perinatology·2026
    Same journal

    A dilemma of parental inclusion? Parent perspectives of NICU feeding practices and neonatal nutritional research.

    Seminars in perinatology·2026
    Same journal

    Maternal diet and nutritional status during pregnancy and lactation: a review of implications on milk composition and lactation outcomes.

    Seminars in perinatology·2026
    See all related articles

    Area of Science:

    • Neonatal physiology
    • Renal medicine
    • Prostaglandin synthesis and function

    Background:

    • The fetal and neonatal kidney synthesizes prostaglandins (PGs) like PGE2, PGD2, PGI2, and PGF2 alpha.
    • These PGs are crucial for regulating renal blood flow (RBF), glomerular filtration rate (GFR), and electrolyte/water excretion.
    • Renal prostaglandin activity and renal function undergo significant changes with advancing gestational and postnatal age.

    Purpose of the Study:

    • To explore the role of prostaglandins in the developmental changes of fetal and neonatal kidney function.
    • To investigate the impact of indomethacin, a prostaglandin inhibitor, on fetal and neonatal renal function.
    • To identify emerging research areas concerning prostaglandins in neonatal renal health.

    Main Methods:

    Related Experiment Videos

  • Review of existing literature on prostaglandin synthesis and function in the developing kidney.
  • Analysis of the effects of maternal and neonatal indomethacin administration on renal parameters.
  • Identification of current research trends in urinary prostaglandins and neonatal renal function.

    • Main Results:

    • Prostaglandins (PGE2, PGD2, PGI2) significantly influence RBF, free water clearance, urine flow, and natriuresis.
    • Changes in prostaglandin synthesis/catabolism correlate with developmental alterations in RBF, GFR, and excretion.
    • Indomethacin treatment can lead to decreased fetal urine output and transient, dose-related neonatal renal dysfunction.

    Conclusions:

    • Prostaglandins play a critical role in the functional development of the fetal and neonatal kidney.
    • Indomethacin therapy requires careful consideration of dosage, timing, and infant's condition due to potential renal side effects.
    • Future research should focus on urinary prostaglandins as hypertension markers and the interplay between antenatal steroids and neonatal renal function.