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Updated: Jan 25, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

28.7K

[Biomarkers of intrauterine growth restriction]

Ewa Gulczyńska1, Ewa Peterson2, Tomasz Radzik2

  • 1Klinika Neonatologii, Instytut Centrum Zdrowia Matki Polki W Łodzi, Łódź, Polska.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 4, 2019
PubMed

Insights

Intrauterine growth restriction (IUGR) impacts 10% of pregnancies, increasing risks. Early diagnosis and effective therapies are lacking, necessitating research into novel biomarkers for better fetal development outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatology
  • Fetal Medicine

Background:

  • Intrauterine growth restriction (IUGR) affects approximately 10% of pregnancies, with higher rates in monochorionic twins.
  • IUGR is linked to significantly increased perinatal mortality and adverse outcomes post-birth and later in life.
  • Current diagnostic methods lack reliability for early detection, and effective treatments remain elusive.

Purpose of the Study:

  • To review recent advancements in identifying potential biomarkers for intrauterine growth restriction (IUGR).
  • To explore biomarkers detectable during pregnancy and in umbilical cord blood for improved diagnosis and management.
  • To highlight progress towards accurate prophylaxis and efficient treatment strategies for IUGR.

Main Methods:

  • Literature review of recent clinical trials and research studies on IUGR.
  • Analysis of potential diagnostic biomarkers for intrauterine growth restriction (IUGR).
  • Evaluation of biomarkers for early detection, prophylaxis, and treatment of IUGR.

Main Results:

  • Identification of promising biomarkers for intrauterine growth restriction (IUGR) detection during pregnancy.
  • Umbilical cord blood analysis reveals potential markers for postnatal assessment of IUGR.
  • Progress in developing diagnostic algorithms and therapeutic approaches for IUGR.

Conclusions:

  • Novel biomarkers show potential for earlier and more accurate diagnosis of intrauterine growth restriction (IUGR).
  • Biomarker discovery is crucial for improving prophylaxis and developing efficient treatments for IUGR.
  • Further research into biomarkers can mitigate the severe consequences of IUGR on fetal development and long-term health.

Keywords:
biomarkersintrauterine growth restriction (IUGR)miRNApregnancy

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