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Updated: Jan 25, 2026

Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain
Published on: October 8, 2021
Adult Neurogenesis, Glia, and the Extracellular Matrix
Elise C Cope1, Elizabeth Gould1
1Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ 08544, USA.
Abstract:
In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive to experience and may participate in hippocampal functions, including learning and memory, anxiety and stress regulation, and social behavior. Increasing evidence emphasizes the importance of new neuron connectivity within hippocampal circuitry for understanding the impact of adult neurogenesis on brain function. In this Review, we discuss how the functional consequences of new neurons arise from the collective interactions of presynaptic and postsynaptic neurons, glial cells, and the extracellular matrix, which together form the "tetrapartite synapse."
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