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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Perivascular space fluid contributes to diffusion tensor imaging changes in white matter.

Farshid Sepehrband1, Ryan P Cabeen1, Jeiran Choupan2

  • 1Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA.

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|May 4, 2019
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Summary
This summary is machine-generated.

Diffusion tensor imaging (DTI) findings in neurological disorders may be biased by perivascular space (PVS) fluid. Advanced multi-shell diffusion MRI can help correct for this bias, improving diagnostic accuracy.

Keywords:
BiasDiffusion tensor imagingPerivascular space

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Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Radiology

Background:

  • Diffusion tensor imaging (DTI) is widely used to detect neurological disorders.
  • Common DTI findings include altered white matter integrity in neurodegenerative diseases.

Purpose of the Study:

  • To investigate the impact of perivascular space (PVS) fluid on DTI measures.
  • To explore the potential of multi-shell diffusion imaging to mitigate PVS-related biases.

Main Methods:

  • Utilized multi-shell diffusion imaging techniques.
  • Separated diffusion signals from brain parenchyma and non-parenchymal PVS fluid.

Main Results:

  • Found that PVS fluid significantly and systematically biases conventional DTI measures.
  • Demonstrated that PVS influences white matter integrity metrics.

Conclusions:

  • Previously reported DTI findings in neurological disorders may require re-evaluation due to PVS bias.
  • Multi-shell diffusion MRI offers a promising approach to account for PVS, enhancing DTI's clinical and scientific value.