Temporal evolution of myeloperoxidase and galectin 3 during 1 year after acute coronary syndrome admission

Related Experiment Video

Updated: Jan 25, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.7K

Maxime M Vroegindewey1, Victor J van den Berg2, Elke Bouwens1

  • 1Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Department of Cardiology, Rotterdam, The Netherlands.

American Heart Journal
|May 5, 2019
PubMed

Insights

Biomarkers Myeloperoxidase and Galectin-3 indicate coronary plaque vulnerability. This study tracked their levels in acute coronary syndrome patients over one year to understand their role in recurrent events.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Clinical Medicine

Background:

  • Myeloperoxidase and Galectin-3 are established biomarkers linked to coronary plaque vulnerability.
  • Elevated levels of these biomarkers have been observed in patients experiencing acute coronary syndrome (ACS).

Purpose of the Study:

  • To investigate the temporal changes in Myeloperoxidase and Galectin-3 levels in ACS patients.
  • To assess the predictive value of these biomarker dynamics for recurrent ACS events within a one-year follow-up period.

Main Methods:

  • Prospective observational study design.
  • Serial measurements of Myeloperoxidase and Galectin-3 post-ACS admission.
  • Clinical follow-up for recurrent ACS events over 12 months.

Main Results:

  • The study tracked the dynamic changes in Myeloperoxidase and Galectin-3 levels over time.
  • Analysis focused on the relationship between biomarker trajectories and subsequent ACS events.

Conclusions:

  • Understanding the temporal patterns of Myeloperoxidase and Galectin-3 may offer insights into ACS risk stratification.
  • Further research can explore therapeutic strategies targeting these biomarkers to prevent recurrent cardiovascular events.

More Related Videos

Complementation of Splicing Activity by a Galectin-3 - U1 snRNP Complex on Beads08:48

Complementation of Splicing Activity by a Galectin-3 - U1 snRNP Complex on Beads

Published on: December 9, 2020

2.5K
Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA07:18

Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA

Published on: May 12, 2023

4.6K

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
912
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
300
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
398
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
238
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
246
The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.7K