Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

4.2K
Commitment is the  process whereby stem cells:
4.2K
Sternberg's Triangular Theory of Love02:15

Sternberg's Triangular Theory of Love

44.9K
We typically love the people with whom we form relationships, but the type of love we have for our family, friends, and lovers differs. Robert Sternberg (1986) proposed that there are three components of love: intimacy, passion, and commitment. These three components form a triangle that defines multiple types of love: this is known as Sternberg’s triangular theory of love. Intimacy is the sharing of details and intimate thoughts and emotions. Passion is the physical attraction—the...
44.9K
Longitudinal Research02:20

Longitudinal Research

13.2K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.2K
Cognitive Dissonance01:38

Cognitive Dissonance

36.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Social Exchange Theory02:06

Social Exchange Theory

39.5K
We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003).
39.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.

Nature microbiology·2026
Same author

Gain-of-function PfAAT1 mutations compensate for impaired PfCRT function in Plasmodium falciparum.

Research square·2026
Same author

The CCCH-type zinc-finger <i>Pf</i> MD3 promotes translation for malaria parasite transmission.

bioRxiv : the preprint server for biology·2026
Same author

ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability.

PLoS pathogens·2026
Same author

Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues.

ACS medicinal chemistry letters·2026
Same author

Dynamic regulation of long non-coding RNAs across asexual and gametocyte development in <i>Plasmodium falciparum</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Shaping an image: 3D-printable models of parasites.

Trends in parasitology·2026
Same journal

Sequencing parasite genomes, one worm at a time.

Trends in parasitology·2026
Same journal

Hidden diversity in Trichuris control.

Trends in parasitology·2026
Same journal

The second Cryptosporidium meeting: Edinburgh's parasite deep dive.

Trends in parasitology·2026
Same journal

Evolution of generalism under Muller's ratchet.

Trends in parasitology·2026
Same journal

Next generation in parasitology 2026: Connecting young parasitologists across Europe.

Trends in parasitology·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.8K

Commitment Isn't for Everyone.

Gabrielle A Josling1, Manuel Llinás2

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA; Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.

Trends in Parasitology
|May 5, 2019
PubMed
Summary
This summary is machine-generated.

Malaria parasite transmission relies on sexual gametocytes. A new study reveals a direct sexual conversion pathway, bypassing parasite replication, crucial for understanding malaria lifecycle and control.

Keywords:
Plasmodium falciparumcommitmentgametocytemalariasexual stage

More Related Videos

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.4K
Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics
07:21

Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics

Published on: June 6, 2025

477

Related Experiment Videos

Last Updated: Jan 25, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.8K
Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

Published on: July 29, 2018

9.4K
Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics
07:21

Live Cell Imaging with Time Lapse Photography to Study Epidermal Keratinocyte Proliferation Kinetics

Published on: June 6, 2025

477

Area of Science:

  • Malariology
  • Parasitology
  • Molecular Biology

Background:

  • Malaria parasites (Plasmodium) must differentiate into gametocytes for mosquito transmission.
  • Asexual parasite stages dominate human infections and are not directly transmissible.
  • Understanding gametocyte development is key to blocking malaria transmission.

Purpose of the Study:

  • To investigate novel pathways for sexual differentiation in malaria parasites.
  • To determine if sexual conversion can occur without prior asexual replication.

Main Methods:

  • Utilized in vitro culture systems for Plasmodium falciparum.
  • Employed microscopy and molecular markers to track parasite development and sexual conversion.

Main Results:

  • Identified a direct conversion route from asexual parasites to transmissible gametocytes.
  • This sexual conversion pathway does not necessitate a preceding round of asexual replication.

Conclusions:

  • A previously unrecognized mechanism for gametocyte formation exists in malaria parasites.
  • This finding offers new targets for interventions aimed at interrupting malaria transmission.