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Updated: Jan 25, 2026

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons
Published on: February 10, 2016
Actin-tropomyosin distribution in non-muscle cells
Dietmar J Manstein1,2,3, J C M Meiring4, E C Hardeman4
1Institute for Biophysical Chemistry, OE4350, Medizinische Hochschule Hannover, 30625, Hannover, Germany. manstein.dietmar@mh-hannover.de.
Abstract:
The interactions of cytoskeletal actin filaments with myosin family motors are essential for the integrity and function of eukaryotic cells. They support a wide range of force-dependent functions. These include mechano-transduction, directed transcellular transport processes, barrier functions, cytokinesis, and cell migration. Despite the indispensable role of tropomyosins in the generation and maintenance of discrete actomyosin-based structures, the contribution of individual cytoskeletal tropomyosin isoforms to the structural and functional diversification of the actin cytoskeleton remains a work in progress. Here, we review processes that contribute to the dynamic sorting and targeted distribution of tropomyosin isoforms in the formation of discrete actomyosin-based structures in animal cells and their effects on actin-based motility and contractility.
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