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Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait

Alaa Mohamed AbdelKader1,2,3, May Fouad Nassar2,4

  • 1Paediatric Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt.

Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = Al-Majallah Al-Sihhiyah Li-Sharq Al-Mutawassit
|May 5, 2019
PubMed

Insights

Low vitamin D levels increase the risk of wheezing in Kuwaiti preschoolers. Addressing vitamin D deficiency may help prevent and manage wheezing illnesses in children.

Area of Science:

  • Pediatric Pulmonology
  • Nutritional Immunology

Background:

  • Emerging evidence highlights vitamin D's crucial extra-skeletal functions, particularly in respiratory health.
  • Vitamin D deficiency is increasingly recognized as a potential factor in lung disease development.

Purpose of the Study:

  • To investigate the association between vitamin D status and the occurrence of wheezing in preschool children in Kuwait.
  • To explore the potential role of vitamin D in different types of wheezing episodes.

Main Methods:

  • A case-control study involving 151 wheezing preschool children and 83 controls from Al-Adan Hospital, Kuwait.
  • Serum 25-hydroxyvitamin D [25(OH)D] levels were measured and compared between groups.
  • Wheezers were categorized into episodic wheezers (EW) and multiple trigger wheezers (MTW) for further analysis.

Main Results:

  • Children with wheezing exhibited significantly lower serum 25(OH)D levels compared to controls.
  • Lower serum 25(OH)D levels were identified as a risk factor for wheezing.
  • While not significantly different between EW and MTW, low serum 25(OH)D showed a potential association with MTW.

Conclusions:

  • Vitamin D deficiency is linked to an increased risk of wheezing in Kuwaiti preschoolers.
  • A potential association between low vitamin D and multiple trigger wheezing suggests a specific role in atopy.
  • Prompt assessment and management of vitamin D deficiency are recommended for children experiencing wheezing.
Abstract

Keywords:
Kuwaitasthmaearly wheezingpre-school childrenserum hydroxyvitamin D

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