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Histamine alters environmental place preference in planaria.

Kara Adams1, Tom Byrne1

  • 1Massachusetts College of Liberal Arts, United States.

Neuroscience Letters
|May 5, 2019
PubMed
Summary

Histamine, a known punisher in vertebrates, was tested for aversive effects in planaria. Results show planaria avoid areas associated with histamine, suggesting conserved behavioral responses to this chemical.

Keywords:
AversionHistaminePhototaxisPlanariaPreference

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Area of Science:

  • Neuroscience
  • Invertebrate Behavior
  • Pharmacology

Background:

  • Histamine acts as a punisher in vertebrate models.
  • Invertebrate responses to histamine's aversive effects are largely unexamined.
  • Planaria exhibit place preferences for light when paired with certain psychoactive drugs.

Purpose of the Study:

  • To investigate if planaria develop conditioned place aversions to histamine.
  • To explore conserved behavioral responses between invertebrates and vertebrates.

Main Methods:

  • Planaria were confined to a darkened side of a petri dish with histamine or freshwater.
  • Behavior was assessed by measuring time spent in lighted vs. darkened areas.
  • Motility assays were used to control for general activity changes.

Main Results:

  • Planaria confined with histamine spent more time in the light compared to controls.
  • This conditioned place aversion occurred in both individual and group tests.
  • Histamine did not fully override the innate preference for darkness and had no effect on motility.

Conclusions:

  • Planaria can develop conditioned place aversions to histamine.
  • These findings suggest conserved behavioral effects of histamine across invertebrates and vertebrates.
  • This adds to evidence for shared neurochemical mechanisms between planaria and vertebrates.