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[Status quo and countermeasure of clopidogrel resistance predicted by gene testing]

Xiaosai Zhang1, Yan Wang

  • 1Department of Neurology, the Affiliated Hospital of Qingdao University, Shandong 266071, China.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|May 6, 2019
PubMed

Insights

Genetic testing can identify clopidogrel resistance, a condition where patients don't respond well to antiplatelet therapy. This helps personalize treatment to prevent cardiovascular events.

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Medicine
  • Clinical Pharmacy

Background:

  • Clopidogrel is a vital antiplatelet medication.
  • Individual responses to clopidogrel vary, leading to clopidogrel resistance in some patients.
  • This resistance can result in recurrent cardio- and cerebrovascular thrombosis.

Purpose of the Study:

  • To review the current understanding of clopidogrel resistance.
  • To explore the role of genetic testing in predicting and managing clopidogrel resistance.
  • To discuss strategies for addressing clopidogrel resistance based on genetic factors.

Main Methods:

  • Review of existing literature on clopidogrel resistance and genetic polymorphisms.
  • Analysis of the application of genetic testing in antiplatelet therapy.
  • Evaluation of methods for predicting clopidogrel resistance through genetic markers.

Main Results:

  • Genetic polymorphism is a primary cause of individual differences in clopidogrel response.
  • Genetic testing enables the assessment of antiplatelet therapy efficacy.
  • Testing can guide therapeutic adjustments and predict thromboembolic event risk.

Conclusions:

  • Genetic testing is crucial for identifying patients at risk of clopidogrel resistance.
  • Personalized antiplatelet therapy based on genetic profiles can improve patient outcomes.
  • Further research and clinical application of genetic testing are needed to combat clopidogrel resistance.

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