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Association between interleukin-10 gene polymorphisms and severe chronic periodontitis
Mohaddeseh Emampanahi1, Saba Masoudi Rad2, Marie Saghaeian Jazi3
1Department of Oral medicine, Dental faculty, Babol University of Medical Sciences, Babol, Iran.
Oral Diseases
|May 6, 2019
Summary
Genetic variations in interleukin-10 (IL-10) may influence periodontitis risk. The IL-10 -1082(G/A) polymorphism and AGC haplotype were linked to chronic periodontitis susceptibility in an Iranian population.
Area of Science:
- Genetics
- Immunology
- Periodontology
Background:
- Periodontitis is an inflammatory oral disease driven by bacterial infection and host immune response.
- Genetic factors, particularly in cytokine genes like interleukin-10 (IL-10), may modulate susceptibility to periodontitis.
- Investigating IL-10 gene polymorphisms offers insights into the genetic predisposition to periodontitis.
Purpose of the Study:
- To examine the association between IL-10 gene polymorphisms and haplotypes and the risk of chronic periodontitis.
- To determine if specific genotype and haplotype frequencies of IL-10 differ between periodontitis patients and healthy individuals in an Iranian population.
- To identify potential genetic markers for periodontitis susceptibility.
Main Methods:
- A case-control study involving 64 periodontitis patients and 128 healthy controls from Iran.
- Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used to analyze IL-10 promoter polymorphisms at -1082 (G/A), -819 (C/T), and -592 (C/A).
- Genotype and haplotype frequencies were statistically analyzed to assess their association with periodontitis risk.
Main Results:
- No significant association was found for IL-10 -592 (C/A) and -819 (C/T) alleles and genotypes with periodontitis risk.
- The GG genotype at IL-10 -1082 (G/A) was more frequent in healthy subjects, indicating a decreased risk of periodontitis (OR = 2.89, p = 0.039).
- Haplotype analysis revealed a significantly higher frequency of the AGC haplotype (H7) in periodontitis patients (OR < 0.0001).
Conclusions:
- The IL-10 -1082(G/A) polymorphism may play a role in modulating the risk of developing chronic periodontitis.
- The AGC (-592/-1082/-819) haplotype of the IL-10 gene is significantly associated with increased susceptibility to chronic periodontitis.
- These findings suggest that specific IL-10 genetic variations could serve as biomarkers for periodontitis risk.
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