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Host Genetics, Diet, and Microbiome: The Role of AMY1
Sofía Morán-Ramos1, María Teresa Villarreal-Molina2, Samuel Canizales-Quinteros3
1Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City 03940, Mexico; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City 14610, Mexico.
Abstract:
Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. (Cell Host Microbe 2019;25;553-564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics-diet-microbiome interactions and their effect on obesity could eventually translate into personalized nutrition.
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