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Updated: Jan 25, 2026
Visualization of Surface-tethered Large DNA Molecules with a Fluorescent Protein DNA Binding Peptide
Published on: June 23, 2016
Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa
Keith A Josephs1, Melissa E Murray2, Nirubol Tosakulwong3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Introduction:
Primary age-related tauopathy (PART) is characterized by the presence of neurofibrillary tangles and absent-minimal β-amyloid deposition. Transactive response DNA-binding protein of 43 kDa (TDP-43), a third protein, has recently garnished a lot of attention in Alzheimer's disease where it is associated with memory loss and amygdala and hippocampal atrophy. We aimed to determine whether TDP-43 is associated with brain atrophy in PART.
Methods:
We assessed the frequency of TDP-43 in PART and performed voxel-level analysis in SPM12, as well as region-of-interest analysis using linear regression modeling, controlling for variables of interest, to assess for associations between TDP-43 and brain atrophy.
Results:
Of 116 PART cases, 31 (26.7%) had TDP-43. The presence of TDP-43 was associated with significantly greater amygdala, hippocampal, and anterior temporal atrophy in both the region-of-interest and the voxel level analyses.
Discussion:
TDP-43 is associated with greater brain atrophy in PART.
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