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Updated: Jan 25, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Transcribe this way: Rap1 confers promoter directionality by repressing divergent transcription
Andrew C K Wu1, Folkert J Van Werven1
1a Cell Fate and Gene Regulation Laboratory , The Francis Crick Institute , London , UK.
Abstract:
In eukaryotes, divergent transcription is a major source of noncoding RNAs. Recent studies have uncovered that in yeast, the transcription factor Rap1 restricts transcription in the divergent direction and thereby controls promoter directionality. Here, we summarize these findings, propose regulatory principles, and discuss the implications for eukaryotic gene regulation.
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