Related Experiment Video
Updated: Jan 25, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Prognostic Factors of Long-Term Hearing Preservation in Small and Medium-Sized Vestibular Schwannomas After
Zirong Huo1,2,3, Jianqing Chen1,2,3, Zhaoyan Wang1,2,3
1Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital.
Objective:
The authors evaluated the long-term hearing outcomes of patients with vestibular schwannoma (VS) to explore appropriate surgical treatment.
Study Design:
Retrospective study.
Setting:
Tertiary referral center.
Patients:
A total of 138 patients diagnosed with small and medium-sized VS with serviceable hearing from January 2006 to December 2015.
Interventions:
All patients underwent microsurgery via retrosigmoid (RSA) or middle cranial fossa approach (MFA) and were followed up for over 2 years.
Main Outcome Measures:
Pre- and postoperative hearing, including pure tone audiometry, speech discrimination score, and auditory brainstem response (ABR), were analyzed.
Results:
The mean tumor size and volume were 16.6 ± 3.4 mm and 1711.8 ± 918.5 mm, respectively. Preoperative hearing levels were Class A in 42, Class B in 67, and Class C in 29 patients. Patients with a tumor from the superior vestibular nerve (SVN) had better hearing at diagnosis. Postoperative hearing levels were Class A, B, C, and D for 28, 17, 32, and 61 patients. Hearing outcomes were significantly better in patients with normal intraoperative I wave on ABR. Hearing loss within 6 months had a positive effect on postoperative hearing. Better preoperative hearing and tumors from SVN were correlated with better postoperative hearing outcomes. Tumor size, cystic variation, or extension to the fundus of internal auditory canal had no influence on hearing preservation.
Conclusions:
Better preoperative hearing, shorter hearing loss period, tumors from SVN, and normal intraoperative I wave are prognostic factors for serviceable hearing. RSA and MFA are effective and safe for tumor removal and hearing preservation.
Related Concept Videos
Hearing
Factors Affecting Dissolution: Particle Size and Effective Surface Area
The Vestibular System
Long-term Depression
Genome Size and the Evolution of New Genes
Cell Size
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...

