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Updated: Jan 25, 2026
12:41
Stress-induced Antibiotic Susceptibility Testing on a Chip
Published on: January 8, 2014
6.9K
Current and Emerging Methods of Antibiotic Susceptibility Testing.
Zeeshan A Khan1, Mohd F Siddiqui2, Seungkyung Park3
1School of Mechanical Engineering, Korea University of Technology and Education, Cheonan, Chungnam 31253, Korea. iamzak@koreatech.ac.kr.
Diagnostics (Basel, Switzerland)
|May 7, 2019
Summary
Rapid antibiotic susceptibility testing (AST) is crucial for treating bacterial infections and combating antibiotic resistance. This review covers traditional and novel AST methods, their benefits, drawbacks, and future challenges.
Area of Science:
- Clinical microbiology
- Infectious diseases
- Diagnostic technology
Background:
- Antibiotic resistance poses a significant socio-economic burden and threat to public health.
- Effective antibiotic susceptibility testing (AST) is vital for guiding patient treatment and preventing the spread of infections.
Purpose of the Study:
- To review the socio-economic impact of antibiotic resistance.
- To provide an overview of phenotypic, genotypic, and emerging antibiotic susceptibility testing (AST) methods.
- To discuss the advantages, limitations, and future outlook of AST.
Main Methods:
- Historical review of conventional AST methods (disk diffusion, Etest, microdilution).
- Critical evaluation of emerging AST techniques (microfluidic-based optical and electrochemical).
- Discussion of challenges and future trends in AST.
Main Results:
- Conventional AST methods have evolved into modern techniques.
- Emerging AST methods offer potential for faster and more accurate diagnostics.
- Significant challenges remain in AST implementation and development.
Conclusions:
- Rapid AST is essential for effective management of bacterial infections.
- A comprehensive understanding of various AST methods is necessary for clinical application.
- Future research should focus on overcoming current AST challenges to improve patient outcomes.
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