Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rotation of Asymmetric Top01:11

Rotation of Asymmetric Top

1.5K
By definition, a spherically symmetric body has the same moment of inertia about any axis passing through its center of mass. This situation changes if there is no spherical symmetry. Since most rigid bodies are not spherically symmetric, these require special treatment.
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
1.5K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

9.7K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
9.7K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.8K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.8K
IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations01:08

IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations

1.8K
Identical bonds within a polyatomic group can stretch symmetrically (in-phase) or asymmetrically (out-of-phase). Similar to hydrogen bonding, these vibrations also influence the shape of the IR peak. Generally, asymmetric stretching frequencies are higher than symmetric stretching frequencies. For example, primary amines exhibit two distinct IR peaks between 3300–3500 cm−1 corresponding to the symmetric and asymmetric N-H stretching, while secondary amines exhibit a single...
1.8K
Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

Matrix-Assisted Laser Desorption Ionization (MALDI)

1.0K
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...
1.0K
Base Excision Repair01:54

Base Excision Repair

26.2K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of base temperature, immersion medium, and EM grid material on devitrification thresholds in cryogenic optical super-resolution microscopy.

Journal of structural biology·2025
Same author

Cryo-iCLEM: Cryo correlative light and electron microscopy with immersion objectives.

Journal of structural biology·2025
Same author

Model-Based Optimization of Solid-Supported Micro-Hotplates for Microfluidic Cryofixation.

Micromachines·2024
Same author

2PP-Hydrogel Covered Electrodes to Compensate for Media Effects in the Determination of Biomass in a Capillary Wave Micro Bioreactor.

Biosensors·2024
Same author

A High-Aspect-Ratio Deterministic Lateral Displacement Array for High-Throughput Fractionation.

Micromachines·2024
Same author

A Flexible Double-Sided Curvature Sensor Array for Use in Soft Robotics.

Sensors (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jan 25, 2026

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq
04:54

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq

Published on: March 19, 2021

5.2K

Robust Smartphone Assisted Biosensing Based on Asymmetric Nanofluidic Grating Interferometry.

Foelke Purr1,2, Max-Frederik Eckardt3, Jonas Kieserling4

  • 1Institute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany. f.purr@tu-braunschweig.de.

Sensors (Basel, Switzerland)
|May 7, 2019
PubMed
Summary

This study introduces a novel smartphone-based sensor for rapid, on-site medical diagnostics. The device offers stable, reliable measurements unaffected by temperature, simplifying healthcare decisions outside traditional facilities.

Keywords:
biosensingcommon mode rejectioninterferometrynanofluidicoptofluidic gratingportable point-of-care (POC)smartphone-based

More Related Videos

Smartphone Fundus Photography
05:51

Smartphone Fundus Photography

Published on: July 6, 2017

40.1K
Assessment of Spatial Lingual Tactile Sensitivity using a Gratings Orientation Test
06:00

Assessment of Spatial Lingual Tactile Sensitivity using a Gratings Orientation Test

Published on: September 17, 2021

3.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq
04:54

Iterative Development of an Innovative Smartphone-Based Dietary Assessment Tool: Traqq

Published on: March 19, 2021

5.2K
Smartphone Fundus Photography
05:51

Smartphone Fundus Photography

Published on: July 6, 2017

40.1K
Assessment of Spatial Lingual Tactile Sensitivity using a Gratings Orientation Test
06:00

Assessment of Spatial Lingual Tactile Sensitivity using a Gratings Orientation Test

Published on: September 17, 2021

3.0K

Area of Science:

  • Biomedical Engineering
  • Optofluidics
  • Sensor Technology

Background:

  • Point-of-care (POC) systems are crucial for timely therapeutic decisions, especially in resource-limited settings.
  • Sensitive and stable measurements by non-experts outside laboratories are essential for effective POC diagnostics.
  • Environmental factors like temperature pose significant challenges to POC sensor reliability and simplicity.

Purpose of the Study:

  • To develop a smartphone-based POC sensor that minimizes environmental interference.
  • To enable sensitive, real-time detection of biomolecules without labeling.
  • To create a robust and user-friendly diagnostic tool for field applications.

Main Methods:

  • Utilized an optofluidic grating with alternating detection and reference channels for differential measurement.
  • Integrated a compact optical setup with a smartphone application for mobile readout.
  • Functionalized detection channels with biotin to capture specific molecules like streptavidin.

Main Results:

  • Demonstrated that ambient temperature variations do not affect sensor signal stability.
  • Successfully measured real-time accumulation of specific molecules (streptavidin) via biotin binding.
  • Achieved label-free detection of biomolecular interactions.

Conclusions:

  • A mobile, reliable, and robust POC device was successfully realized.
  • The integrated differential measurement concept and smartphone readout enhance usability and accuracy.
  • This technology holds promise for accessible diagnostics in diverse settings.