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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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[Eosinophilic granulomatosis with polyangiitis: 30 cases report]
1Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China (Zhang Mengyuan is working in the Department of Respiratory, Liaocheng People's Hospital, Shandong Province, Liaocheng 252000, China).
Zhonghua Yi Xue Za Zhi
|May 7, 2019
Summary
Eosinophilic granulomatosis with polyangiitis (EGPA) presents with diverse symptoms, often including asthma and rhinitis. This study highlights the complex and individualistic nature of EGPA manifestations, predominantly affecting females.
Area of Science:
- Rheumatology
- Pulmonology
- Pathology
Background:
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis.
- Understanding EGPA's diverse clinical spectrum is crucial for timely diagnosis and management.
Purpose of the Study:
- To enhance comprehension of Eosinophilic granulomatosis with polyangiitis (EGPA).
- To detail the clinical, laboratory, imaging, and pathological features of EGPA patients.
Main Methods:
- A retrospective study of 30 EGPA patients.
- Data collection included clinical manifestations, laboratory findings, imaging, and pathology.
Main Results:
- The majority of EGPA patients (86.7%) had asthma, with rhinitis/nasosinusitis (90.0%) being highly prevalent.
- Common findings included peripheral eosinophilia (76.7%) and migratory pulmonary infiltrates (70.0%).
- EGPA manifestations were diverse, affecting skin, nerves, heart, and kidneys, with a female predominance.
Conclusions:
- EGPA exhibits highly individualized and complex clinical presentations.
- The absence of pathognomonic symptoms underscores the need for comprehensive evaluation in suspected EGPA cases.
- Female patients were more frequently observed in this cohort.
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