Related Experiment Video

Updated: Jan 25, 2026

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

4.1K

Expert consensus on palivizumab use for respiratory syncytial virus in developed countries

Manuel Sánchez Luna1, Paolo Manzoni2, Bosco Paes3

  • 1Complutense University, Research Institute University Hospital Gregorio Marañon. Neonatology Division, Avda. de Séneca 2, 28040 Madrid, Spain.

Paediatric Respiratory Reviews
|May 8, 2019
PubMed

Insights

New guidelines recommend palivizumab for infants and children at high risk of respiratory syncytial virus (RSV) infection. This monoclonal antibody prophylaxis aims to reduce hospitalizations in vulnerable young populations.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Respiratory syncytial virus (RSV) is a major cause of childhood hospitalization.
  • Palivizumab is the sole licensed preventive intervention for RSV.
  • Updated guidelines are crucial, considering recent evidence, cost-effectiveness, and healthcare budgets.

Framework:

  • A systematic review of nearly 400 publications over five years informed the recommendations.
  • RSV experts from Europe, Canada, and Israel collaborated on the evidence-based guidelines.
  • Recommendations focus on prophylaxis in industrialized nations.

Implementation:

  • Palivizumab is recommended for specific high-risk groups, including preterm infants (e.g., <29, ≤31 weeks gestational age) and those up to 24 months with chronic lung disease, congenital heart disease, Down syndrome, pulmonary/neuromuscular disorders, immunocompromise, or cystic fibrosis.
  • Up to five monthly doses are advised during the RSV season.
  • Guidelines target infants and children up to 24 months of age, with specific gestational age and age criteria for preterm infants.

Implications:

  • Adoption of these guidelines is expected to decrease the burden of RSV hospitalizations in children.
  • Optimized palivizumab prophylaxis can improve health outcomes for high-risk pediatric populations.
  • Evidence-based recommendations support informed clinical decision-making for RSV prevention.

Keywords:
Evidence-based medicineLower respiratory tract infectionNeonatal lung diseasePalivizumabRespiratory syncytial virus

More Related Videos

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.5K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.1K

Related Concept Videos

What are Viruses?00:50

What are Viruses?

Overview
127.9K
Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
3.4K
The Respiratory System01:16

The Respiratory System

The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
89.2K
Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
5.0K
Overview of Respiratory System01:23

Overview of Respiratory System

The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
9.3K
Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
2.9K