Related Experiment Video
Updated: Jan 25, 2026

Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
Alexis R Cole1, Dorothy A Perry1,2, Ali Raza1,2
1Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
Abstract:
This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a complementary therapy that can be easily incorporated into current workflows. In the future, inhaled hydrogen may diminish the sequelae of ischemia that occurs in congenital heart surgery, cardiac arrest, extracorporeal life-support events, acute myocardial infarction, stroke, and organ transplantation.
Related Concept Videos
Anatomy of the Circulatory System
Gas Exchange and Transport
Hydrogen Bonds
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
Hydrogen Bonds
Inhaled Medications
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...

