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Updated: Jan 25, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Synthetic Haptens and Monoclonal Antibodies to the Cyanotoxin Anatoxin-a
Guillermo Quiñones-Reyes1,2, Consuelo Agulló1, Josep V Mercader3
1Department of Organic Chemistry, University of Valencia, Doctor Moliner 50, 46100 Burjassot, Valencia, Spain.
Abstract:
Early warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin-a, a cyanotoxin involved in numerous cases of animal poisoning resulting from toxic algal blooms in freshwaters. Through the synthesis of three functionalized derivatives of anatoxin-a, we have succeeded in generating the first-ever reported immunoreagents (bioconjugates and antibodies) suitable for the development of immunoanalytical approaches aimed at rapid and onsite detection of this harmful cyanotoxin.
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