Virology: Poxins Soothe the STING
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Alexiane Decout1, Andrea Ablasser1
1Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Current Biology : CB
|May 8, 2019
Abstract:
The mammalian cyclic dinucleotide 2',3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2',3'-cGAMP-specific nucleases allowing immune evasion by viruses.
