Unexpected Friendship: Neutrophils Help Tumor Cells En Route to Metastasis
1Department of Stem Cell Biology and Regenerative Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Developmental Cell
|May 8, 2019
Abstract:
Circulating tumor cells (CTCs) contain metastatic precursors that can initiate new metastases. Recent work shows that association with neutrophils provides a proliferative advantage to CTCs, rendering them more competent in metastasis formation. The study identifies molecular players in CTC-neutrophil interactions, providing potential targets for disrupting formation of these deadly metastatic seeds.
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