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In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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Selecting target papers for replication.
Anton Kuehberger1, Michael Schulte-Mecklenbeck2
1Centre for Cognitive Neuroscience,University of Salzburg,Salzburg 5020,Austria.anton.kuehberger@sbg.ac.athttps://ccns.sbg.ac.at/people/kuehberger/.
The Behavioral and Brain Sciences
|May 9, 2019
Summary
Replication success hinges on random paper selection. Biased selection, based on ease or doubt, increases replication failure rates, impacting scientific reproducibility.
Area of Science:
- Psychology
- Social Sciences
- Reproducibility Studies
Background:
- Replication studies are crucial for verifying scientific findings.
- The selection process for replication targets can influence outcomes.
- Previous target selection methods may have introduced bias.
Purpose of the Study:
- To examine the impact of selection bias on replication success.
- To highlight the importance of randomness in choosing replication targets.
- To advocate for unbiased selection in future replication efforts.
Main Methods:
- Analysis of the selection criteria for replication targets.
- Comparison of outcomes between randomly selected and non-randomly selected targets.
- Literature review on existing replication methodologies.
Main Results:
- Randomness in target paper selection is critical for successful replication.
- Biased selection, driven by replication ease or skepticism, correlates with higher failure rates.
- Current selection practices for replication targets are demonstrably biased.
Conclusions:
- Implementing random selection processes is essential for robust replication studies.
- Addressing selection bias is key to improving the reliability of scientific research.
- Unbiased selection enhances the integrity and validity of the scientific record.
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