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Updated: Jan 25, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Advances in Clinical Cardiology 2018: A Summary of Key Clinical Trials
Katie Linden1, Conor McQuillan2, Paul Brennan2
1Craigavon Cardiac Centre, SHSCT, Craigavon, Northern Ireland, UK. kmslinden@gmail.com.
Insights
Key 2018 cardiology trials are reviewed, covering interventional, preventative, and electrophysiology advances. These significant findings offer clinical context for practitioners and researchers in cardiovascular medicine.
Area of Science:
- Cardiology
- Clinical Trials
- Cardiovascular Medicine
Background:
- 2018 saw numerous pivotal clinical trials presented at major cardiology conferences.
- These trials represent significant advancements in cardiovascular medicine.
Purpose of the Study:
- To provide a concise overview of key 2018 cardiology clinical trials.
- To place these significant advances into clinical context for clinicians and researchers.
Main Methods:
- Reviewed trials presented at major international cardiology meetings in 2018.
- Conducted a literature search for relevant clinical cardiology publications.
- Included trials with potential impact on clinical practice and future guidelines.
Main Results:
- 78 trials met inclusion criteria, covering interventional, preventative, and electrophysiology areas.
- Interventional data included novel stent designs, drug-coated balloons, and transcatheter valve interventions.
- Preventative data focused on SGLT2 inhibitors, PCSK9 inhibitors, and hypertension management.
Conclusions:
- The article summarizes crucial 2018 clinical trials in cardiology.
- Findings are valuable for both cardiology clinicians and researchers.
Introduction:
Many important clinical trials in cardiology were published or presented at major international meetings throughout 2018. This paper aims to offer a concise overview of these significant advances and to put them into clinical context.
Methods:
Trials presented at the major international cardiology meetings during 2018 were reviewed including The American College of Cardiology, EuroPCR, The European Society of Cardiology, PCR London Valves, Transcatheter Cardiovascular Therapeutics, and the American Heart Association. In addition to this a literature search identified several other publications eligible for inclusion based on their relevance to clinical cardiology, their potential impact on clinical practice and on future guidelines.
Results:
A total of 78 trials met the inclusion criteria. New interventional and structural data include trials examining novel stent designs (Biofreedom™, COMBO), use of drug-coated balloons in patients with high bleeding risk, intervention in stable coronary artery disease, revascularisation strategy in ST elevation myocardial infarction, transcatheter aortic valve replacement in low-risk patients, and percutaneous mitral or tricuspid valve interventions. Preventative cardiology data included the use of sodium glucose cotransporter-2 inhibitors (empagliflozin, dapagliflozin, canagliflozin), proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (alirocumab) and approaches of hypertension management. Antiplatelet data included trials evaluating both the optimal length of course and combination of antiplatelet agents. Heart failure data included trials of sacubitril-valsartan during acute hospital admission and the management of chemotherapy-induced cardiotoxicity. Electrophysiology data included trials examining atrial fibrillation ablation, wearable cardiac defibrillators (LifeVest) and His-bundle pacing.
Conclusion:
This article presents key clinical trials completed during 2018 and should be valuable to both cardiology clinicians and researchers.
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