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Updated: Jan 25, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Covalently linked meso-tetraaryl triphyrin(2.1.1)-ferrocene(s) conjugates: synthesis and properties
Kamakshya Nath Panda1, Kishor G Thorat1, Mangalampalli Ravikanth1
1Indian Institute of Technology, Powai, Mumbai, 400076, India. ravikanth@chem.iitb.ac.in.
Abstract:
Functionalized meso-tetraaryl triphyrins(2.1.1) containing two meso-iodophenyl groups or a bromo group at the β-pyrrole carbon were synthesized over a sequence of steps. The covalently linked conjugates such as a triphyrin(2.1.1)-(ferrocene)2 triad and a triphyrin(2.1.1)-ferrocene dyad were obtained in 47-51% yields by coupling the appropriate functionalized triphyrin with ethynylferrocene under mild Pd(0) coupling reaction conditions. The functionalized triphyrins(2.1.1) and their conjugates were thoroughly characterized by HR-mass spectrometry and 1D and 2D NMR spectroscopy. The absorption, electrochemical and DFT studies suggested weak interactions between the triphyrin(2.1.1) and ferrocenyl moieties in triads but relatively strong interactions in dyads.
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