Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K
Design Example: Maintaining Level of an Embankment01:19

Design Example: Maintaining Level of an Embankment

419
Constructing a roadway embankment over uneven terrain requires precise leveling to ensure stability and proper drainage. Surveyors use a leveling instrument and staff to calculate ground elevations and determine the required fill material at each point along the embankment alignment.The process begins by positioning a leveling instrument near a benchmark with a known elevation. A backsight reading establishes the instrument height, which serves as a reference for subsequent measurements. A...
419
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.2K
Humoral Immune Responses01:36

Humoral Immune Responses

83.5K
Overview
83.5K
Active versus Passive Immunity01:31

Active versus Passive Immunity

10.1K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
10.1K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

16.7K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes.

Science immunology·2025
Same author

Heterozygous loss of MAP4K1 causes immune dysregulation by amplifying T-cell responses.

The Journal of allergy and clinical immunology·2025
Same author

Clinical spectrum of primary hemophagocytic lymphohistiocytosis: experience of reference centers in Central and Southeast Anatolia.

Annals of hematology·2024
Same author

Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.

Nature immunology·2024
Same author

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis.

Blood·2024
Same author

High-dimensional single-cell analysis of human natural killer cell heterogeneity.

Nature immunology·2024

Related Experiment Video

Updated: Jan 25, 2026

Maintaining Wolbachia in Cell-free Medium
13:33

Maintaining Wolbachia in Cell-free Medium

Published on: July 4, 2007

10.8K

IL2RB maintains immune harmony.

Tessa M Campbell1, Yenan T Bryceson2

  • 1Center for Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

The Journal of Experimental Medicine
|May 10, 2019
PubMed
Summary

The interleukin-2 receptor beta-chain (IL-2RB) is crucial for immune function and tolerance. Autosomal recessive mutations in IL2RB highlight its essential role in maintaining a healthy immune system.

More Related Videos

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

8.3K
Maintaining Aedes aegypti Mosquitoes Infected with Wolbachia
09:23

Maintaining Aedes aegypti Mosquitoes Infected with Wolbachia

Published on: August 14, 2017

14.7K

Related Experiment Videos

Last Updated: Jan 25, 2026

Maintaining Wolbachia in Cell-free Medium
13:33

Maintaining Wolbachia in Cell-free Medium

Published on: July 4, 2007

10.8K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

8.3K
Maintaining Aedes aegypti Mosquitoes Infected with Wolbachia
09:23

Maintaining Aedes aegypti Mosquitoes Infected with Wolbachia

Published on: August 14, 2017

14.7K

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • The specific immunological functions of the interleukin-2 receptor beta-chain (IL-2RB) have been largely unknown.
  • Understanding IL-2RB's role is critical for deciphering immune regulation and tolerance mechanisms.

Purpose of the Study:

  • To investigate the function of IL-2RB in immunity and peripheral immune tolerance.
  • To identify genetic factors influencing IL-2RB's role in immune health.

Main Methods:

  • Analysis of autosomal recessive mutations in the IL2RB gene.
  • Observational studies on individuals with IL2RB mutations.

Main Results:

  • Independent reports identified the first cases of autosomal recessive mutations in IL2RB.
  • These mutations demonstrate a critical requirement for IL2RB in immune responses.
  • The findings reveal IL2RB's necessity for maintaining peripheral immune tolerance.

Conclusions:

  • IL2RB is essential for proper immune function.
  • Mutations in IL2RB impair immunity and peripheral immune tolerance.
  • This research clarifies the enigmatic role of IL-2RB in the immune system.