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IL2RB maintains immune harmony

Tessa M Campbell1, Yenan T Bryceson2

  • 1Center for Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

The Journal of Experimental Medicine
|May 10, 2019
PubMed

How the IL-2 receptor β-chain specifically shapes immunity has remained enigmatic. In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20182304) and Fernandez et al. (https://doi.org/10.1084/jem.20182015) independently report the first observations of autosomal recessive mutations in IL2RB, revealing a requirement for IL2RB in immunity and peripheral immune tolerance.

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