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An Apical Resection Model in the Adult Xenopus tropicalis Heart
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[Endoprosthetic replacement following intercalary resection].

L Goebel1, D Kohn1, P Orth2

  • 1Klinik für Orthopädie und Orthopädische Chirurgie, Universitätsklinikum des Saarlandes, Kirrberger Straße 100, Gebäude 37-38, 66421, Homburg/Saar, Deutschland.

Der Orthopade
|May 10, 2019
PubMed
Summary

Endoprosthetic replacement offers a valuable option for intercalary bone defect reconstruction after tumor resection. While short-term results are favorable, long-term complications may limit its use, particularly in younger patients.

Keywords:
Allogenic bone transplantationAutologous bone transplantationCallotasisDiaphysisSarcoma

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Area of Science:

  • Orthopedic Oncology
  • Reconstructive Surgery
  • Biomaterials Engineering

Background:

  • Intercalary resection of diaphyseal bone tumors necessitates reconstructive strategies.
  • Endoprosthetic replacement is a key treatment for such bone defects.

Purpose of the Study:

  • To review indications, surgical techniques, and available implants for alloplastic reconstruction of segmental bone defects.
  • To evaluate literature results and alternative procedures for diaphyseal bone reconstruction.

Main Methods:

  • Comprehensive literature review of clinical studies and authors' experiences.
  • Analysis of data on endoprosthetic survival rates and biological reconstruction alternatives.

Main Results:

  • 10-year survival rates for intercalary endoprostheses range from 64-80%, though comparisons are challenging.
  • Biological alternatives include bone grafting, distraction osteogenesis, and induced membrane techniques.
  • Tissue engineering approaches are currently in preclinical stages.

Conclusions:

  • Segmental endoprostheses demonstrate satisfactory short- to mid-term outcomes, offering immediate weight-bearing advantages over biological methods.
  • Endoprostheses are often favored in elderly or palliative cases due to potential long-term complications.