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Related Concept Videos

Chirality02:25

Chirality

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Chirality in Nature02:30

Chirality in Nature

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
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Overview of the Reproductive System01:31

Overview of the Reproductive System

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The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
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Buffers: Overview01:30

Buffers: Overview

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Buffers play a crucial role in stabilizing the pH of a solution by mitigating the effects of small amounts of added acid or base. They consist of a weak acid and its conjugate base or a weak base and its conjugate acid. A solution of acetic acid and sodium acetate is an example of a buffer that consists of a weak acid and its salt: CH3COOH (aq) + CH3COONa (aq). An example of a buffer that consists of a weak base and its salt is a solution of ammonia and ammonium chloride: NH3 (aq) + NH4Cl (aq).
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Updated: Jan 25, 2026

A Micropatterning Assay for Measuring Cell Chirality
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Cyclofructans as Chiral Selectors: An Overview.

Garrett Hellinghausen1, Daniel W Armstrong2

  • 1Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|May 10, 2019
PubMed
Summary
This summary is machine-generated.

Cyclofructans, versatile chiral selectors, are key for separating enantiomers using chromatography. Their application in liquid chromatography, particularly with superficially porous particles, shows significant advancements.

Keywords:
Crown ethersCycloinuloheptaoseCycloinulohexaoseDerivatized cyclofructansDimethylphenyl-cyclofructanEnantiomeric separationsIsopropyl-cyclofructanPrimary aminesR-naphthylethyl-cyclofructanSulfated-cyclofructanSuperficially porous particles

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Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Area of Science:

  • Carbohydrate Chemistry
  • Analytical Chemistry
  • Separation Science

Background:

  • Cyclofructans are cyclic oligosaccharides composed of β-2,1-linked fructofuranose units.
  • They are widely recognized for their potential as chiral selectors in various chromatographic techniques.

Purpose of the Study:

  • To review the development and applications of cyclofructans as chiral selectors.
  • To emphasize their use in liquid chromatography, especially with superficially porous particles (SPPs).

Main Methods:

  • Review of literature on cyclofructans in chiral separation techniques.
  • Focus on applications in high-performance liquid chromatography (HPLC) and other chromatographic methods.
  • Discussion of method parameters and future research directions.

Main Results:

  • Cyclofructans, often after derivatization, have demonstrated efficacy as chiral selectors in HPLC, GC, CE, and SFC.
  • Significant improvements in liquid chromatography separations are noted with the use of SPPs.

Conclusions:

  • Cyclofructans are effective chiral selectors with broad applicability in chromatographic separations.
  • Further advancements are expected, particularly in liquid chromatography utilizing SPPs.