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CD146 (Cluster of Differentiation 146)

Aurélie S Leroyer1, Muriel G Blin1, Richard Bachelier1

  • 1From the Aix-Marseille University, Center for CardioVascular and Nutrition Research, INSERM 1263, INRA 1260, France (A.S.L., M.G.B., R.B., N.B., M.B.-C., F.D.-G.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|May 10, 2019
PubMed

Insights

Cluster of differentiation 146 (CD146) is a key adhesion molecule regulating vessel functions. Research highlights its roles in angiogenesis, vascular permeability, and leukocyte transmigration, crucial for vascular homeostasis.

Area of Science:

  • Vascular Biology
  • Cell Adhesion Molecules
  • Endothelial Cell Function

Background:

  • Cluster of differentiation 146 (CD146) is an adhesion molecule expressed on endothelial cells and other vascular cells.
  • CD146 plays a critical role in regulating various vascular functions.
  • Three CD146 forms exist: two transmembrane isoforms and a soluble plasma protein.

Purpose of the Study:

  • To review current knowledge on the functions of CD146 in vascular homeostasis.
  • To explore the involvement of CD146 in diseases linked to endothelial dysfunction.
  • To summarize the pleiotropic functions mediated by CD146 interactions.

Main Methods:

  • Review of scientific literature over the past 30 years.
  • Analysis of studies employing neutralizing antibodies, siRNA, and genetically modified mice.
  • Focus on research demonstrating CD146's role in angiogenesis, vascular permeability, and leukocyte transmigration.

Main Results:

  • CD146 mediates diverse functions through homophilic and heterophilic interactions.
  • Evidence supports CD146's involvement in regulating angiogenesis, vascular permeability, and leukocyte transmigration.
  • CD146 is integral to maintaining vascular homeostasis.

Conclusions:

  • CD146 is a pivotal molecule in vascular biology.
  • Understanding CD146's role is essential for addressing endothelial dysfunction and related diseases.
  • Further research into CD146 functions can inform therapeutic strategies for vascular disorders.

Keywords:
animalsendothelial cellshomeostasismiceprotein isoforms

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