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Updated: Jan 25, 2026

Preparation of Decellularized Kidney Scaffolds in Rats
Published on: March 18, 2021
Immunogenicity analysis of decellularized cardiac scaffolds after transplantation into rats
Cailing Tong1,2,3, Junjie Xia2,3, Baiyi Xie2,3
1School of Life Science, Xiamen University, Fujian, 361102, China.
Abstract:
Aim: Cardiac extracellular matrix (cECM) scaffolds are promising biomaterials for clinical applications. Our aim is to determine the immunogenicity of decellularized scaffolds from different sources for use as artificial organs during organ transplantation. Materials & methods: We transplanted Lewis rats with syngeneic (Lewis rat cECM), allogeneic (BN rat cECM) or xenogeneic (hamster cECM) decellularized cardiac scaffolds. Acute vascular and cellular rejection was quantified by immunohistochemistry and immune cell infiltration. Results: BN rat and hamster hearts were rejected following transplantation. BN and hamster cECMs had similarly low immunogenicity compared with Lewis rat cECMs and did not lead to increased rejection. Conclusion: We found that scaffolds from all sources did not induce vascular or cellular rejection and exhibited low immunogenicity.
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