Related Experiment Video
Updated: Jan 25, 2026
22:06
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
Published on: February 25, 2007
14.0K
Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources
Reem Elfeky1, Arina Lazareva1, Waseem Qasim1
1a Blood and bone marrow transplant unit , Great Ormond Street hospital , London , UK.
Expert Review of Clinical Immunology
|May 10, 2019
Summary
Hematopoietic stem cell transplantation (HSCT) success depends on immune recovery. This review examines how stem cell source, serotherapy, and novel techniques impact immune reconstitution post-HSCT.
Area of Science:
- Immunology
- Hematology
- Transplantation Medicine
Background:
- Immune reconstitution is critical for successful hematopoietic stem cell transplantation (HSCT).
- Factors influencing immune recovery include patient characteristics and transplant-related variables.
- Understanding immune recovery patterns is essential for optimizing transplant outcomes.
Purpose of the Study:
- To systematically review the literature on immune recovery following HSCT.
- To analyze the impact of different stem cell sources (bone marrow, peripheral blood stem cells, cord blood) on immune reconstitution.
- To evaluate the influence of serotherapy and explore novel strategies for enhancing immune recovery.
Main Methods:
- Systematic literature search of PubMed, Scopus, and international congress abstracts.
- Review of studies focusing on immune recovery patterns post-HSCT.
- Analysis of data concerning stem cell source, serotherapy, and emerging techniques.
Main Results:
- Cord blood grafts promote a CD4+ biased immune reconstitution.
- Targeted serotherapy with cord grafts enhances immune recovery and limits alloreactivity.
- Two haploidentical approaches (TCRαβ/CD19 depletion and post-cyclophosphamide HSCT) show comparable survival and reduced alloreactivity.
Conclusions:
- Stem cell source and serotherapy significantly impact immune reconstitution post-HSCT.
- Novel strategies, including modified haploidentical approaches, are improving transplant outcomes.
- Further advancements, such as modified donor lymphocyte infusions, are needed to address delayed immune recovery.
Related Concept Videos
01:19Multipotency of Hematopoietic Stem Cells
3.9K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.9K
01:01Regulation of Hematopoietic Stem Cells
4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K
01:27Source And Potency Of Stem Cells
6.2K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
6.2K
01:13Induced Pluripotent Stem Cells
27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
01:33Adult Stem Cells
33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
00:58Embryonic Stem Cells
32.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.1K