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Ivermectin: From theory to clinical application
1Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
International Journal of Antimicrobial Agents
|May 10, 2019
Summary
Ivermectin (IVM) is widely used for parasitic diseases and vector control. Emerging resistance necessitates research into novel drug delivery systems to enhance its efficacy and expand its therapeutic potential.
Area of Science:
- Pharmacology
- Tropical Medicine
- Parasitology
Background:
- Ivermectin (IVM) is an annual treatment for approximately 250 million individuals globally, targeting parasitic infections like filariasis, onchocerciasis, strongyloidiasis, scabies, and pediculosis.
- Clinical studies confirm IVM's efficacy, optimal dosage, and treatment duration for numerous parasitic diseases.
- IVM also demonstrates efficacy against disease vectors such as mosquitoes, sandflies, and tsetse flies, supporting public health initiatives by organizations like the WHO.
Purpose of the Study:
- To review the established human applications of ivermectin (IVM).
- To highlight emerging properties and potential new uses of IVM.
- To discuss the challenges of drug resistance and novel delivery systems for IVM.
Main Methods:
- Literature review of clinical studies on ivermectin (IVM) efficacy.
- Analysis of IVM's role in disease control programs.
- Exploration of recent research on novel drug delivery systems for IVM.
Main Results:
- Ivermectin (IVM) is effective against a broad spectrum of parasitic infections and disease vectors.
- The World Health Organization (WHO) utilizes IVM in programs for onchocerciasis and lymphatic filariasis elimination and malaria reduction.
- Parasite resistance to IVM is an emerging concern, prompting investigation into new therapeutic strategies.
Conclusions:
- Ivermectin (IVM) remains a crucial antiparasitic agent with expanding applications.
- Novel drug delivery systems are being explored to overcome ivermectin resistance and broaden its therapeutic scope.
- Further research is needed to fully elucidate IVM's potential against infections like trichinosis and myiasis.
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