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Updated: Jan 25, 2026

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
Published on: November 20, 2011
LncRNA HOTAIR in Tumor Microenvironment: What Role?
Gerardo Botti1, Giosuè Scognamiglio2, Gabriella Aquino3
1Scientific Direction, Istituto Nazionale Tumori, Fondazione G. Pascale, IRCCS, 80131 Naples, Italy. g.botti@istitutotumori.na.it.
Abstract:
lncRNAs participate in many cellular processes, including regulation of gene expression at the transcriptional and post-transcriptional levels. In addition, many lncRNAs can contribute to the development of different human diseases including cancer. The tumor microenvironment (TME) plays an important role during tumor growth and metastatic progression, and most of these lncRNAs have a key function in TME intracellular signaling. Among the numerous identified lncRNAs, several experimental evidences have shown the fundamental role of the lncRNA HOTAIR in carcinogenesis, also highlighting its use as a circulating biomarker. In this review we described the contribution of HOTAIR in the TME modulation, highlighting its relation with cellular and non-cellular components during tumor evolution and progression.
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