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Wearable Devices for Single-Cell Sensing and Transfection.
Lingqian Chang1, Yu-Chieh Wang2, Faheem Ershad3
1School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Institute of Nanotechnology for Single Cell Analysis (INSCA), Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA.
Trends in Biotechnology
|May 11, 2019
Summary
Wearable micro/nano devices offer advanced real-time biosensing and precise transdermal delivery for cellular monitoring and gene transfection. These innovations show promise for improved healthcare applications in skin and other organs.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Wearable Technology
Background:
- Wearable healthcare devices are pivotal for biosensing and transdermal delivery.
- Advancements in wearable biosensors enable continuous, real-time physiological monitoring at cellular resolution.
- Transdermal drug delivery systems are miniaturized for diverse cargo, including natural and bioengineered molecules.
Purpose of the Study:
- To review recent technical progress in wearable micro/nano devices for biosensing and transfection.
- To highlight devices with potential for single-cell analysis and gene delivery in vivo.
- To suggest future research directions in wearable micro/nano device technology.
Main Methods:
- Review of recent literature on wearable micro/nano devices.
- Analysis of technological advancements in biosensing and transdermal delivery.
- Exploration of single-cell gene transfection capabilities of emerging nanopatches.
Main Results:
- Wearable biosensors achieve long-term, real-time monitoring of physiological conditions.
- Miniaturized transdermal systems facilitate delivery of various molecules, including nanoparticles.
- Emerging nanopatches demonstrate efficient, safe, and controllable single-cell gene transfection in vivo.
Conclusions:
- Wearable micro/nano devices are advancing single-cell biosensing and transfection.
- These technologies offer significant advantages over conventional methods for efficiency and control.
- Future development holds promise for enhanced in vivo applications within skin and other organs.
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