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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Implementing a Population-Based Breast Cancer Risk Assessment Program.

Erica Silver¹, Neil Wenger², Zhuoer Xie¹

¹Department of Hematology and Oncology, David Geffen School of Medicine at University of California, Los Angeles, CA.

Clinical Breast Cancer

|May 11, 2019

Summary

This summary is machine-generated.

Implementing population-based breast cancer risk assessment requires significant effort. Many high-risk women identified initially were excluded, highlighting challenges in referral and follow-up for personalized breast cancer management.

Keywords:

Breast cancer screening Population-based study Risk assessment Risk communication Risk prevention

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Area of Science:

Oncology
Genetics
Public Health

Background:

Personalized breast cancer risk assessment is crucial for managing women at increased risk.
Limited evaluation exists on the practical implementation of population-based programs for identifying and referring high-risk individuals.

Purpose of the Study:

To evaluate the practical aspects of a semiautomated program for identifying and referring high-risk women for breast cancer evaluation.
To assess the effectiveness of breast health genetic counselors (BHGCs) in risk stratification and referral.

Main Methods:

A semiautomated approach was used to collect personal and family history for breast cancer risk assessment.
Women identified as high risk received letters for telephone consultations with licensed breast health genetic counselors (BHGCs).
BHGCs verified risk information, provided counseling, and made referrals as appropriate.

Main Results:

Out of 20,558 women screened, 2000 (9.7%) were initially identified as high risk.
1,580 women were excluded after BHGC review due to prior attention or abnormal mammograms.
Of 225 women who received BHGC consultation, 158 were referred to high-risk clinics, and 51 attended appointments.

Conclusions:

Population-based breast cancer screening programs are complex to implement in clinical settings.
Substantial effort is required to identify and refer newly discovered high-risk women to appropriate breast cancer services.