Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

509
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
509
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

451
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
451
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

496
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
496
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

370
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
370
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

545
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
545
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

332
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
332

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereoretentive Norrish-Yang Photocyclization Mediated by Hydrogen Bonding.

Journal of the American Chemical Society·2026
Same author

Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Journal of cardiovascular translational research·2026
Same author

Catalytic Enantioselective Multicomponent Reactions of Sulfoxonium Ylides Enabled by a Formal Rearrangement-A Versatile Entry to Enantioenriched α-Sulfanyl Carbonyl Compounds.

Angewandte Chemie (International ed. in English)·2026
Same author

Improved Outcome up to Ten Years after Intravenous Immunoglobulin Therapy in Patients with Dilated Cardiomyopathy.

European journal of heart failure·2026
Same author

Ensemble Analyzer: An Open-Source Python Framework for Automated Conformer Ensemble Refinement.

Journal of chemical information and modeling·2026
Same author

Inflammatory Hot Phases and Disease Trajectory in Desmosomal Cardiomyopathies.

Circulation·2026
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026
Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.3K

Dilated cardiomyopathy.

Heinz-Peter Schultheiss1,2, DeLisa Fairweather3, Alida L P Caforio4

  • 1Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany. heinz-peter.schultheiss@charite.de.

Nature Reviews. Disease Primers
|May 11, 2019
PubMed
Summary
This summary is machine-generated.

Dilated cardiomyopathy (DCM) is a heart muscle disease leading to enlarged ventricles and impaired contraction. Identifying the cause is key for personalized treatment and improved outcomes in DCM patients.

More Related Videos

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.9K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.4K

Related Experiment Videos

Last Updated: Jan 25, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.3K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.9K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.4K

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Dilated cardiomyopathy (DCM) involves ventricular dilation and impaired contraction, not explained by other conditions.
  • Causes include genetic mutations (sarcomere, desmosome) and non-genetic factors like infections, toxins, and autoimmune diseases.
  • The varied causes and presentations of DCM complicate diagnosis and treatment.

Purpose of the Study:

  • To review the heterogeneous causes of dilated cardiomyopathy.
  • To discuss diagnostic challenges and current management strategies for DCM.
  • To highlight the importance of etiology-driven personalized care and novel diagnostic tools for DCM.

Main Methods:

  • Review of existing literature on dilated cardiomyopathy.
  • Analysis of diagnostic approaches including imaging and biopsy.
  • Discussion of current and potential therapeutic strategies.

Main Results:

  • DCM has diverse genetic and non-genetic origins, impacting diagnosis.
  • Echocardiography and biopsy are crucial for assessing ventricular dysfunction and inflammation.
  • Standard heart failure treatments are primary, with specific therapies guided by etiology.

Conclusions:

  • Accurate and timely diagnosis of DCM is challenging due to its heterogeneity.
  • An etiology-driven, personalized approach to care, alongside new diagnostic tools like biomarkers, can improve DCM patient outcomes.
  • Integrated diagnostic and therapeutic strategies are essential for managing dilated cardiomyopathy effectively.