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Dermal elastolysis in the setting of combination immunotherapy
Kirsten E Dickinson1, Lulit Price1,2, Karolyn A Wanat1,3,2,4,5
1Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA.
Journal of Cutaneous Pathology
|May 11, 2019
Summary
Programmed cell death protein 1 (PD-1) inhibitors can cause skin issues. This study details papillary dermal elastolysis, a rare side effect, in patients receiving nivolumab and cabiralizumab chemotherapy.
Area of Science:
- Dermatology
- Oncology
- Immunotherapy
Background:
- Immunotherapies, particularly programmed cell death protein 1 (PD-1) inhibitors, are associated with various cutaneous side effects.
- Understanding these side effects is crucial for patient management in cancer treatment.
Observation:
- Two patients developed papillary dermal elastolysis after combination chemotherapy.
- The condition presented as skin-colored, wrinkled papules and atrophic macules.
- This occurred following an initial inflammatory eruption.
Findings:
- Papillary dermal elastolysis is a novel finding in patients treated with nivolumab and cabiralizumab.
- Elastolysis, a breakdown of elastic fibers, was observed in the papillary dermis.
- This specific side effect appears linked to this particular combination immunotherapy regimen.
Implications:
- Highlights a previously unreported cutaneous adverse event associated with specific cancer immunotherapies.
- Suggests the need for increased dermatological surveillance in patients undergoing treatment with nivolumab and cabiralizumab.
- Contributes to the growing body of knowledge on immune-related adverse events in oncology.
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