Related Experiment Video
Updated: Jan 25, 2026
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Freezing of gait and dementia in parkinsonism: A retrospective case-control study
Giovanni Palermo1, Daniela Frosini1, Andrea Corsi1
1Department of Clinical and Experimental Medicine, Unit of Neurology, University of Pisa, Pisa, Italy.
Objectives:
To support the cognitive model of Freezing of Gait (FoG) we investigated FoG in a cohort of patients with Dementia with Lewy Bodies (DLB).
Materials And Methods:
We assessed FoG frequency in 19 DLB patients compared to 19 control PD patients within 2 years from symptom onset and with at least 5 years follow-up. The two groups were matched by age and motor presentation at onset, severity of parkinsonism and disease duration. The presence and severity of FoG was identified as those with a score of 1 or greater on subitem 14 of the Unified Parkinson's Disease Rating Scale Part II (UPDRS II).
Results:
At T0, 68.4% DLB and 10.5% PD patients experienced FoG ≥1. The prevalence of FoG increased with disease progression (94.7% DLB and 47.3% PD subjects had FoG ≥1 at T5). DLB also showed a more severe FoG (FoG ≥2) than PD (21% vs. 0% at T0 and 52.6% vs. 10.5% at T5), consistently with previous studies reporting FoG prevalence in DLB.
Conclusion:
This is the first study looking specifically at FoG in DLB, identifying it as a frequent and early feature of DLB and emphasizing the crucial role of cognitive impairment in the occurrence of this mysterious phenomenon.
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