Efficacy of autologous platelet rich fibrin in bone augmentation and bone regeneration at extraction socket

The purpose of the present study is to provide the efficacy of autologous platelet rich fibrin in bone augmentation and bone regeneration procedures in regard of soft and hard tissue healing in oral surgery treatment.

An electronic search on PubMed database was performed regarding the placement of autologous platelet rich fibrin at tooth extraction sockets, bone and soft tissue augmentation procedures associated with implant placement and infrabony defects. The search was constrained to English language articles published during last five years and includes only clinical trials.

In total, 25 articles were included in this literature review. The studies were divided into five main groups, depending on the application: 1) utilization of autologous platelet rich fibrin at 3rd molar extraction sockets preservation, 2) any extraction socket preservation, 3) bone augmentation/sinus lift procedures with implant placement, 4) augmentation of peri-implant tissues, and 5) treatment of infrabony defects.

The application of autologous platelet rich fibrin (PRF) show benefits in promoting soft tissue healing and bone regeneration in different surgical procedures. Furthermore, it is an autologous biomaterial which has low cost and does not need administration of any additives. Nevertheless, further studies with a bigger sample size and longer follow up duration are necessary to facilitate more substantial evidence of the efficacy of PRF in promotion of soft and hard tissue healing.