Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K
Tumor Progression02:07

Tumor Progression

7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
Electrical Current01:10

Electrical Current

6.9K
Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
6.9K
Significance of Displacement Current01:27

Significance of Displacement Current

5.8K
A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
5.8K
Current Trends in Nursing I01:28

Current Trends in Nursing I

5.3K
Current trends in nursing include:
5.3K
Current Trends in Nursing II01:30

Current Trends in Nursing II

3.4K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical window of opportunity clinical trial of abemaciclib and letrozole for endometrioid adenocarcinoma of the endometrium.

Gynecologic oncology·2026
Same author

Cesium-131 brachytherapy for central nervous system salvage therapy.

Journal of neuro-oncology·2026
Same author

BET inhibition disrupts the FOXM1-MYC axis to induce BRCAness and enhance PARP inhibitor response.

NPJ precision oncology·2026
Same author

Utilization of Key Morphologic and Molecular Prognostic and Predictive Parameters in Endometrial Malignancies: A Survey of Gynecologic Pathologists.

International journal of surgical pathology·2026
Same author

Ovarian cancer cell glucocorticoid receptor activation increases myeloid-derived suppressor cell tumor infiltration.

Endocrinology·2026
Same author

Identifying premenopausal patients with early-stage hormone receptor-positive breast cancer at minimal risk of distant recurrence by breast cancer index.

Breast (Edinburgh, Scotland)·2026

Related Experiment Video

Updated: Jan 25, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

2.0K

Current recommendations and recent progress in endometrial cancer.

Rebecca A Brooks1,2, Gini F Fleming3, Ricardo R Lastra4

  • 1Associate Professor, Department of Gynecologic Oncology, The University of Chicago, Chicago, IL.

CA: a Cancer Journal for Clinicians
|May 11, 2019
PubMed
Summary

Endometrial cancer, a common gynecologic malignancy, is increasing. While new treatments like anti-programmed cell death protein 1 immunotherapy show promise for metastatic disease, controversies in surgical lymph node assessment and adjuvant therapy selection persist.

Keywords:
endometrial cancerhealth disparitiesmicrosatellite instabilityuterine cancer

More Related Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.1K
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.6K

Related Experiment Videos

Last Updated: Jan 25, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

2.0K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.1K
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.6K

Area of Science:

  • Gynecologic Oncology
  • Cancer Biology
  • Immunotherapy

Background:

  • Endometrial cancer is the most prevalent gynecologic malignancy in the US, with a rising incidence.
  • Recent advancements in understanding endometrial cancer biology have been made.
  • Treatment strategies, particularly concerning surgical lymph node assessment and adjuvant therapy selection, remain subjects of debate.

Purpose of the Study:

  • To review the current landscape of endometrial cancer treatment.
  • To highlight areas of ongoing controversy in management.
  • To discuss emerging therapeutic strategies, including immunotherapy.

Main Methods:

  • Literature review of recent advancements in endometrial cancer research.
  • Analysis of current treatment controversies.
  • Overview of immunotherapy applications in metastatic endometrial cancer.

Main Results:

  • Pembrolizumab (anti-programmed cell death protein 1 immunotherapy) is approved for microsatellite-instable, metastatic endometrial cancer.
  • Ongoing clinical trials are exploring further applications of immunotherapy.
  • Key treatment decisions regarding lymph node assessment and adjuvant therapies require careful consideration.

Conclusions:

  • Despite progress, significant controversies persist in endometrial cancer treatment.
  • Immunotherapy represents a promising frontier for specific subsets of patients.
  • Further research is crucial to refine treatment protocols and improve patient outcomes.