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Updated: Jan 25, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
Role of identified RNA N6-methyladenosine methylation in liver
Kechen Xu1, Yuchao Sun2, Baixiang Sheng2
1Clinical Laboratory Center, Wuyi First People's Hospital, Wuyi, 321200, Zhejiang, China.
Abstract:
N6-Methyladenosine (m6A) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. m6A RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA), microRNA (miRNA) and long noncoding RNA (lncRNA). And m6A methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that m6A RNA modification highly regulates hepatic function and development of liver diseases. Here, we aim to summarize the biological and clinical significance of m6A modification in hepatic growth and hepatic disease including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and liver cancer.
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