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Updated: Jan 25, 2026
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A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
Published on: May 12, 2023
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New Targeted Therapies for Uncontrolled Asthma
1Departments of Medicine and Pediatrics, Division of Allergy and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, Calif.
Summary
New biologic therapies targeting specific pathways are improving asthma treatment. While current options are effective for many, research continues into novel agents for severe and non-type 2 asthma.
Area of Science:
- Immunology
- Pulmonology
- Pharmacology
Background:
- Mechanistic studies have advanced understanding of asthma's molecular and cellular underpinnings.
- Current biologic therapies include antibodies targeting IgE, IL-5, IL-5R, and IL-4R, offering add-on treatment for allergic and eosinophilic asthma.
Purpose of the Study:
- To review the current landscape of asthma biologics and emerging therapeutic targets.
- To discuss the potential of new agents for patients with inadequately controlled severe asthma, including non-type 2 disease.
Main Methods:
- Review of established and investigational biologic therapies for asthma.
- Analysis of clinical trial data for novel asthma drug candidates.
Main Results:
- Approved biologics (omalizumab, reslizumab, mepolizumab, benralizumab, dupilumab) are effective for specific asthma phenotypes.
- Several novel agents targeting thymic stromal lymphopoietin, CRTH2, KIT, GATA3, IL-33/ST2, IL-25, IL-6, and others are under investigation.
Conclusions:
- Existing biologics have improved severe asthma management but do not benefit all patients.
- Ongoing and future clinical trials are crucial to determine the efficacy of new targeted therapies for severe allergic, eosinophilic, and non-type 2 asthma.
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