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The Discovery of Q Fever and Its Cause
1Emeritus Professor of Medicine, University of Washington, Seattle Washington.
Abstract:
An outbreak of a febrile illness among workers in a slaughterhouse in Brisbane, Australia led E.H. Derrick to discover a new infection, which he labeled Q fever. Almost simultaneously, investigators in Montana discovered a new organism in ticks that caused fever in guinea pigs. Eventually, investigators found that the Q fever and tick microbes were identical. Outbreaks of Q fever occurred in laboratories, and epidemics of it affected both Axis and Allied troops in Europe during World War II, but it was only afterwards that an explanation emerged about what the major reservoir of the organism was and how infection was most commonly transmitted to animals and humans.
Insights
Q fever, a new infection discovered in Australia, was later found to be caused by the same microbe found in ticks in Montana. Understanding its transmission and reservoirs came after World War II.
Area of Science:
- Infectious Diseases
- Microbiology
- Veterinary Medicine
Background:
- Q fever was first identified in Australian slaughterhouse workers by E.H. Derrick.
- A concurrent discovery in Montana identified a novel tick-borne organism causing fever in guinea pigs.
- These two discoveries were later unified, revealing the same causative agent for both.
Discussion:
- The organism responsible for Q fever was identified as Coxiella burnetii.
- Outbreaks occurred in laboratory settings and during World War II, affecting military personnel.
- The major animal reservoirs and human transmission routes were elucidated post-war.
Key Insights:
- Q fever is a zoonotic disease with a global distribution.
- Ticks serve as a significant vector for Coxiella burnetii.
- Understanding transmission is crucial for preventing occupational and epidemic spread.
Outlook:
- Continued research into Coxiella burnetii pathogenesis and epidemiology.
- Development of improved diagnostic and control strategies for Q fever.
- Public health awareness regarding zoonotic disease risks in animal industries.
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