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Roles of integrin in tumor development and the target inhibitors

Zhao-He Li1, You Zhou1, You-Xiang Ding1

  • 1State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.

Chinese Journal of Natural Medicines
|May 12, 2019
PubMed

Insights

Integrins, cell adhesion molecules, are crucial in cell interactions and tumor development. Targeting integrins offers a promising strategy for novel cancer therapies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Integrins are cell adhesion molecules mediating cell-cell and cell-extracellular matrix interactions.
  • Integrins regulate critical cellular processes including proliferation, differentiation, adhesion, and migration.
  • Aberrant integrin expression is linked to tumor formation, progression, and metastasis.

Purpose of the Study:

  • To review the multifaceted role of integrins in tumor development.
  • To summarize the current landscape of integrin-targeting drugs for cancer treatment.

Main Methods:

  • Literature review of studies on integrin function in cancer.
  • Analysis of preclinical and clinical data on integrin inhibitors.

Main Results:

  • Integrins significantly influence tumor cell differentiation, migration, proliferation, and neovascularization.
  • Integrin inhibitors demonstrate therapeutic potential in various cancer models.

Conclusions:

  • Integrins are pivotal in tumorigenesis and represent a promising therapeutic target.
  • Further research into integrin inhibitors is essential for advancing cancer treatment.
Keywords:
IntegrinNatural medicinesTarget therapyTumor development

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