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Related Experiment Video

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Abnormal thalamocortical network dynamics in migraine.

Yiheng Tu1, Zening Fu1, Fang Zeng1

  • 1From the Department of Psychiatry (Y.T., N.M., J.P., G.W., J.K.), Massachusetts General Hospital and Harvard Medical School, Charlestown; The Mind Research Network (Z.F., V.C.), Albuquerque, NM; Acupuncture and Tuina School/3rd Teaching Hospital (F.Z., L.L., Z.L., F.L.), Chengdu University of Traditional Chinese Medicine, Chengdu; Traditional Chinese Medicine School (Y.G.), Ningxia Medical University, Yinchuan; and The Acupuncture and Tuina School (M.L.), Hunan University of Chinese Medicine, Changsha, China.

Neurology
|May 12, 2019
PubMed
Summary
This summary is machine-generated.

Migraine patients exhibit altered brain connectivity patterns, with abnormal thalamocortical network function linked to headache frequency. This suggests a transient pathologic state in the migraine brain.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Brain Connectivity

Background:

  • Migraine is a complex neurological disorder.
  • Thalamocortical networks play a crucial role in brain function.
  • Understanding dynamic functional connectivity in migraine is essential.

Purpose of the Study:

  • To investigate dynamic functional connectivity (dFNC) in thalamocortical networks of interictal migraine patients.
  • To determine if clinical features are associated with abnormal connectivity.

Main Methods:

  • Studied 89 interictal migraine patients and 70 healthy controls.
  • Utilized sliding window cross-correlation, clustering state analysis, and graph-theory methods.
  • Assessed relationships between clinical symptoms and dFNC using multivariate linear regression.

Main Results:

  • Identified five dFNC brain states.
  • Migraineurs showed increased time in highly connected states and decreased time in sparse states.
  • Abnormal posterior thalamus (pulvinar nucleus) dFNC correlated with headache frequency.
  • Migraineurs exhibited lower global and local information transfer efficiency.

Conclusions:

  • Migraineurs display a transient pathologic state characterized by atypical thalamocortical connectivity.
  • Findings support existing research on abnormal thalamocortical networks and dysrhythmia in migraine.