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Experiments with direct detection of multiple FIDs.

Ēriks Kupče1, Kaustubh R Mote2, Perunthiruthy K Madhu2

  • 1Bruker UK Ltd., Banner Lane, Coventry CV4 9GH, United Kingdom.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 12, 2019
PubMed
Summary
This summary is machine-generated.

Multiple free induction decay (FID) detection in Nuclear Magnetic Resonance (NMR) experiments significantly enhances spectral information and measurement sensitivity. This advanced technique enables parallel acquisition, accelerating structure elucidation and resonance assignment for various samples.

Keywords:
Afterglow magnetizationHadamard encodingHyperpolarizationInterleaved acquisitionMetabolomicsMulti-FID detectionMultiple receiversMultiplex phase cyclingNMR supersequencesParallel NMRParallel spectroscopyReduced dimensionalityResidual polarizationSimultaneous cross-polarizationSolid-state NMRSpatial encodingUltra-fast NMR

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Analytical Chemistry
  • Biophysical Chemistry

Background:

  • Modern Nuclear Magnetic Resonance (NMR) spectrometers are equipped with multiple receivers, enabling parallel data acquisition.
  • Multi-free induction decay (FID) detection strategies have been developed for both homonuclear and multinuclear NMR experiments.
  • These techniques are applicable to liquid-state, solid-state, and hyperpolarized NMR samples.

Purpose of the Study:

  • To provide an overview of multi-FID detection techniques in NMR.
  • To demonstrate the application of multi-FID detection for structure elucidation and resonance assignment.
  • To highlight the benefits of multi-FID detection for increasing NMR system throughput and reducing analysis costs.

Main Methods:

  • Direct observation of multiple free induction decays (FIDs) in pulse schemes.
  • Parallel acquisition of spectra from different nuclear species using multiple receivers.
  • Design of multi-dimensional pulse schemes incorporating simultaneous FID acquisition.
  • Utilizing probes with multiple RF micro-coils connected to multiple NMR receivers.

Main Results:

  • Multi-FID detection significantly increases spectral information content and measurement sensitivity per unit time.
  • Enabled structure elucidation of small molecules and resonance assignment in proteins from a single measurement.
  • Demonstrated substantial improvements in throughput for modern NMR systems.
  • Showcased benefits for both liquid- and solid-state NMR experiments, including those with hyperpolarized samples.

Conclusions:

  • Multi-FID detection is a powerful technique for enhancing NMR experiment efficiency and data richness.
  • It facilitates rapid structure elucidation and resonance assignment, reducing experimental time and cost.
  • This methodology is poised to become an essential component of future NMR systems, improving analytical capabilities.