Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.3K
Overview
51.3K
What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K
Cancer Vaccines01:30

Cancer Vaccines

989
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
989
Zones of Protection01:16

Zones of Protection

785
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
785
Protection of Alcohols02:31

Protection of Alcohols

8.0K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.0K
Protecting Self-Esteem01:27

Protecting Self-Esteem

204
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
204

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic diversity of <i>Bordetella bronchiseptica</i> isolates obtained from primates.

Frontiers in microbiology·2025
Same author

A whole-cell pertussis vaccine engineered to elicit reduced reactogenicity protects baboons against pertussis challenge.

mSphere·2024
Same author

The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation in <i>Bordetella bronchiseptica</i>.

Frontiers in microbiology·2024
Same author

Repeated Bordetella pertussis Infections Are Required to Reprogram Acellular Pertussis Vaccine-Primed Host Responses in the Baboon Model.

The Journal of infectious diseases·2023
Same author

T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination.

Cell host & microbe·2023
Same author

Antigen Discovery for Next-Generation Pertussis Vaccines Using Immunoproteomics and Transposon-Directed Insertion Sequencing.

The Journal of infectious diseases·2022

Related Experiment Video

Updated: Jan 25, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K

Pertussis vaccines and protective immunity.

Parul Kapil1, Tod J Merkel1

  • 1Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring MD 20993, USA.

Current Opinion in Immunology
|May 12, 2019
PubMed
Summary

Pertussis cases are rising despite vaccination. Effective protection against Bordetella pertussis requires both antibody and T-cell immunity, with Th1 and Th17 responses crucial for long-term defense.

More Related Videos

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

11.0K
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
05:39

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

12.6K

Related Experiment Videos

Last Updated: Jan 25, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.2K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

11.0K
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
05:39

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

12.6K

Area of Science:

  • Immunology
  • Vaccinology
  • Infectious Diseases

Background:

  • Reported pertussis cases have increased despite high vaccine coverage.
  • This resurgence necessitates research into host responses for improved vaccine development.
  • Optimal protection against Bordetella pertussis involves both humoral and cellular immunity.

Purpose of the Study:

  • To review current understanding of immune responses to pertussis infection and vaccination.
  • To compare immune responses induced by natural infection, whole-cell vaccines, and acellular vaccines.
  • To elucidate the role of different T-helper cell responses in protection and bacterial clearance.

Main Methods:

  • Literature review of immunological data on pertussis.
  • Analysis of immune responses (Th1, Th17, Th2, antibody) following infection and vaccination.
  • Evaluation of the impact of priming on immune response durability and bias.

Main Results:

  • Natural infection and whole-cell pertussis vaccines induce Th1/Th17 responses.
  • Acellular pertussis vaccines predominantly induce Th2 responses.
  • Th1 and Th17 responses are critical for bacterial clearance and sustained protection, beyond antibody-mediated disease prevention.

Conclusions:

  • Immune response profiles differ significantly between natural infection, whole-cell, and acellular pertussis vaccination.
  • Th1/Th17-mediated immunity is essential for effective bacterial clearance and long-lasting protection against Bordetella pertussis.
  • Understanding the impact of early-life priming is key to developing next-generation pertussis vaccines and vaccination strategies.